The Studies of Anti-Trypanosomal Activity of Selected Plants Extracts against Dimenazene Aceturate® Resistant Strains of Trypanosoma Brucei and T. Congolense Isolates.

Abstract

African trypanosomiasis is a parasitic disease caused by arthropod vectors disease is causing serious threats to the lives of millions people as well as animals, especially cattle worldwide. Plants in Nigeria are known to contain medicinal properties within a large variety of their chemical structures, and many have been screened and tested against anti-trypanosomal activity, with the effort of finding new drugs against the disease on plants and their products with anti-trypanosomal activity from Nigerian flora were surveyed based on the available publication as at the time of compilation of this report. About 40 plants were identified, with 30 compounds as potential active agents and presented in the text. This review indicates the suitability of Nigerian flora in providing a greater advantage in the search for new and efficient trypanocidal molecules that could provide a better result against dimenazene aceturate resistance strains of the parasites to most of the conventional drugs.